Baicalein 7-O-glucuronide
Baicalin
CAS: 21967-41-9;100647-26-5
Molecular Formula: C21H18O11
Baicalein 7-O-glucuronide - Names and Identifiers
| Name | Baicalin |
| Synonyms | Radix Bassora Baicalin BAICALIN HYDRATE Baicalein 7-O-glucuronide BAICALIN 7-BETA-D-GLUCOPYRANOSIDURONATE HYDRATE BAICALEIN 7-BETA-D-GLUCOPYRANOSIDURONATE HYDRATE 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl hexopyranosiduronic acid 5,6-Dihydroxy-4-oxygen-2-phenyl-4H-1-benzopyran-7-beta-D-glucopyranose acid 5,6-Dihydroxy-4-oxygen-2-phenyl-4H-1-benzopyran-7-beta-D-glucopyranose acid 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid |
| CAS | 21967-41-9 100647-26-5 |
| EINECS | 606-866-1 |
| InChI | InChI=1/C21H18O11/c22-9-6-10(8-4-2-1-3-5-8)30-11-7-12(14(23)15(24)13(9)11)31-21-18(27)16(25)17(26)19(32-21)20(28)29/h1-7,16-19,21,23-27H,(H,28,29) |
| InChIKey | IKIIZLYTISPENI-ZFORQUDYSA-N |
Baicalein 7-O-glucuronide - Physico-chemical Properties
| Molecular Formula | C21H18O11 | ||||||
| Molar Mass | 446.36 | ||||||
| Density | 1.737±0.06 g/cm3(Predicted) | ||||||
| Melting Point | 202-205 °C (dec.) (lit.) | ||||||
| Boling Point | 836.6±65.0 °C(Predicted) | ||||||
| Specific Rotation(α) | -85 º (c=1, DMSO) | ||||||
| Flash Point | 297.2°C | ||||||
| Solubility | Soluble in N, N-dimethylformamide, pyridine, soluble in sodium bicarbonate, sodium carbonate, sodium hydroxide and other alkaline solutions, but in the lye unstable, gradual dark brown, slightly soluble in hot glacial acetic acid, insoluble in formic acid, acetic acid, acetone, almost insoluble in water, ether, benzene, chloroform and so on. | ||||||
| Vapor Presure | 1.07E-29mmHg at 25°C | ||||||
| Appearance | Pale yellow crystalline powder | ||||||
| Color | Pale Yellow to Yellow | ||||||
| pKa | 2.72±0.70(Predicted) | ||||||
| Storage Condition | 2-8°C | ||||||
| Stability | Hygroscopic | ||||||
| Refractive Index | 1.739 | ||||||
| MDL | MFCD00134418 | ||||||
| Physical and Chemical Properties |
| ||||||
| Use | Antibacterial, used for purging fire detoxification, hemostasis, tocolysis |
Baicalein 7-O-glucuronide - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | LZ5776910 |
| HS Code | 29329990 |
Baicalein 7-O-glucuronide - Introduction
Pharmacological effects: It has broad-spectrum antibacterial effects, as well as choleretic, anti-inflammatory, anti-allergic, antipyretic, detoxification, diuretic, and antihypertensive effects. It is clinically used to treat infectious hepatitis. It has a good effect on reducing glutamic pyruvic transaminase during the active period of hepatitis. It also uses leaf to treat stroke and paralysis, which can reduce cerebrovascular resistance, increase cerebral blood flow, and improve blood-brain barrier permeability And fight against platelet aggregation caused by adenosine phosphate.
Last Update：2022-10-16 17:15:00
Baicalein 7-O-glucuronide - Reference Information
| Plant source: | Scutellaria baicalensis |
| traits | brown to light yellow crystalline powder; The air is slight and the taste is bitter. |
| use | baicalein has the effects of reducing cerebrovascular resistance, improving cerebral blood circulation, increasing cerebral blood flow and resisting platelet aggregation. It is clinically used for the treatment of paralysis after cerebrovascular disease. used for the treatment of infectious hepatitis, acute jaundice and chronic hepatitis, acute biliary tract infection, lead poisoning and other diseases antibacterial drugs, used for purging fire detoxification, hemostasis, fetal safety has broad-spectrum antibacterial effects, as well as choleretic, anti-inflammatory, anti-allergic, antipyretic, detoxification, diuresis, antihypertensive and other effects. It is clinically used to treat infectious hepatitis. It has a good effect on reducing glutamic pyruvic transaminase during the active period of hepatitis. It also uses leaf to treat stroke and paralysis, which can reduce cerebrovascular resistance, increase cerebral blood flow, and improve blood-brain barrier permeability And fight against platelet aggregation caused by adenosine phosphate. It can absorb ultraviolet rays, scavenge oxygen free radicals, and inhibit the production of melanin A key flavonoid found in the root of Scutellaria baicalensis has antioxidant, anti-inflammatory, anti-tumor and anti-apoptotic activities. |
| overview | baicalin is a flavonoid compound extracted and separated from scutellaria baicalensis root. it is light yellow powder at room temperature and tastes bitter. Insoluble in methanol, ethanol, acetone, slightly soluble in chloroform and nitrobenzene, almost insoluble in water, soluble in hot acetic acid. When it comes to ferric chloride, it will be green, and when it comes to lead acetate, it will produce orange precipitation. Dissolved in alkali and ammonia, it turns yellow at first, and soon turns black-brown. It has significant biological activity, with antibacterial, diuretic, anti-inflammatory, cholesterol-lowering, anti-thrombosis, asthma relief, purging fire and detoxification, hemostasis, pregnancy, anti-allergy and antispasmodic effects, and is also a specific inhibitor of mammalian liver salivary enzyme. It has the effect of regulating certain diseases and has a strong physiological effect of anti-cancer response. Mainly used for the treatment of wet temperature, summer temperature chest tightness and vomiting, damp-heat fullness, diarrhea and jaundice, lung heat cough, high fever and polydipsia, blood heat vomiting, carbuncle swelling and sore poison, fetal movement disorders. In addition, baicalin can also absorb ultraviolet rays, remove oxygen free radicals and inhibit the formation of melanin. It is a good functional cosmetic raw material. |
| source of extraction | obtained by extraction of dried roots of scutellaria (Scutellaria baicalensis Georgi), a dicotyledonous labiaceae plant. |
Last Update：2024-04-09 15:16:48
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